Thursday, March 31, 2011

Lab Update: Prevention of Pathologies of the Auditory System

Just a selection of some of our papers which could be linked to the broad thematic of prevention. We are working among other subjects on some pathologies for which no treatment is available ... thus, a lot of what we did can actually be translated into "prevention" : factors of risks, main causes, mechanisms of vulnerability ... As we mentionned in this blog earlier with the paper of Colleen LePrell, the situation changed a lot in the last decades. Now, the "standard" ear of a young adult is already damaged. Auditory prevention? First, put your headphone at a lower volume. Second, put your tv and radio at a lower volume. Third, put your headphone at a lower volume (yes, same than one, but it is really important). We are all vulnerable to noise. However, the degree of variability is not the same for all of us. Factors underlying individual vulnerability can also been identified using animal models ...

Guitton MJ, Klin Y, Dudai Y (2008) Taste-dependant sociophobia: When food and company do not mix. Behavioural Brain Research, 191:148-152.
Guitton MJ (2006) Tinnitus and anxiety: more than meet the ears. Current Psychiatry Reviews, 2:333-338.
Chabert R, Guitton MJ, Amram D, Uziel A, Lallemant JG, Puel JL (2006) Early maturation of evoked otoacoustic emissions and medial olivocochlear reflex in preterm neonates. Pediatric Research, 59:305-308.
Guitton MJ, Wang J, Puel JL (2004) New pharmacological strategies to restore hearing and to treat tinnitus. Acta Otolaryngol (Stockholm), 124:411-415.
Wang J, Lloyd Faulconbridge RV, Fetoni A, Guitton MJ, Pujol R, Puel JL (2003) Local application of sodium thiosulphate prevents cisplatin-induced hearing loss in the guinea pig. Neuropharmacology, 45:380-393.
Nicolas-Puel C, Lloyd Faulconbridge R, Guitton M, Puel JL, Mondain M, Uziel A (2002) Characteristics of tinnitus and etiology of associated hearing loss : a study of 123 patients. International Tinnitus Journal, 8:37-44.
Delprat B, Boulanger A, Wang J, Beaudoin V, Guitton MJ, Venteo S, Deschesne CJ, Pujol R, Lavigne-Rebillard M, Puel JL, Hamel CP (2002) Down regulation of otospiralin, a novel inner ear protein, causes hair cell degeneration and deafness. Journal of Neuroscience, 22:1718-1725.
Puel JL, Ruel J, Guitton M, Wang J, Pujol R (2002) The inner hair cell synaptic complex: Physiology, pharmacology and new therapeutic strategies. Audiology Neurootology, 7:49-54.
Kossowski M, Mom T, Guitton M, Poncet JL, Bonfils P, Avan P (2001) Fine alterations of distortions-product otoacoustic emissions after moderate acoustic overexposure in guinea pig’s. Audiology, 40:113-122.
Avan P, Wit HP, Guitton M, Mom T, Bonfils P (2000) On the spectral periodocity of transient-evoked otoacoustic emissions from normal and damaged cochleas. Journal of Acoustical Society of America, 108:1117-1127.

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